› 2oie

X-ray diffraction
2.2Å resolution

Crystal structure of RS21-C6 core segment RSCUT

Released:
DOI: 10.2210/pdb2oie/pdb
PDB entry 2oie coloured by chain, front view.
PDB entry 2oie coloured by chain, side view.
PDB entry 2oie coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis.
Wu B, Liu Y, Zhao Q, Liao S, Zhang J, Bartlam M, Chen W, Rao Z
J Mol Biol 367 1405-12 (2007)
PMID: 17320107

Function and Biology Details

Reaction catalysed: 
dCTP + H(2)O = dCMP + diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193049 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
dCTP pyrophosphatase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 111 amino acids
Theoretical weight: 12.64 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9QY93 (Residues: 21-126; Coverage: 62%)
Gene names: Dctpp1, Tdrg-TL1
Sequence domains: MazG-like family
Structure domains: MazG-like

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 53.204Å b: 62.616Å c: 137.927Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.218 0.275
Expression system: Escherichia coli

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Citations

1 review citation

Preventive DNA repair by sanitizing the cellular (deoxy)nucleoside triphosphate pool.
Nagy et al. (2014)
8 other articles

3 mentions without citation

Structural and functional insights into DR2231 protein, the MazG-like nucleoside triphosphate pyrophosphohydrolase from Deinococcus radiodurans.
Gonçalves et al. (2011)
2 more