› 2oj4

X-ray diffraction
2.3Å resolution

Crystal structure of RGS3 RGS domain

Released:
DOI: 10.2210/pdb2oj4/pdb
PDB entry 2oj4 coloured by chain, front view.
PDB entry 2oj4 coloured by chain, side view.
PDB entry 2oj4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
14-3-3 protein interacts with and affects the structure of RGS domain of regulator of G protein signaling 3 (RGS3).
Rezabkova L, Boura E, Herman P, Vecer J, Bourova L, Sulc M, Svoboda P, Obsilova V, Obsil T
J Struct Biol 170 451-61 (2010)
PMID: 20347994

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156046 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulator of G-protein signaling 3 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49796 (Residues: 1064-1190; Coverage: 11%)
Gene name: RGS3
Sequence domains: Regulator of G protein signaling domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: C2
Unit cell:
a: 77.236Å b: 60.849Å c: 57.406Å
α: 90° β: 135.44° γ: 90°
R-values:
R R work R free
0.221 0.193 0.25
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Structural basis of 14-3-3 protein functions.
Obsil et al. (2011)
4 more

2 mentions without citation

Structural basis for the 14-3-3 protein-dependent inhibition of the regulator of G protein signaling 3 (RGS3) function.
Rezabkova et al. (2011)
1 more