› 2ojq

X-ray diffraction
2.87Å resolution

Crystal structure of Alix V domain

Released:
DOI: 10.2210/pdb2ojq/pdb
PDB entry 2ojq coloured by chain, front view.
PDB entry 2ojq coloured by chain, side view.
PDB entry 2ojq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for viral late-domain binding to Alix.
Lee S, Joshi A, Nagashima K, Freed EO, Hurley JH
Nat Struct Mol Biol 14 194-9 (2007)
PMID: 17277784

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186719 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death 6-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 348 amino acids
Theoretical weight: 39.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WUM4 (Residues: 360-702; Coverage: 40%)
Gene names: AIP1, ALIX, KIAA1375, PDCD6IP
Sequence domains: ALIX V-shaped domain binding to HIV
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 5 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21
Unit cell:
a: 37.65Å b: 55.38Å c: 113.166Å
α: 90° β: 92.37° γ: 90°
R-values:
R R work R free
0.257 0.25 0.318
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

35 review citations

The many functions of ESCRTs.
Vietri et al. (2020)
34 more

3 mentions without citation

A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments.
Pires et al. (2009)
2 more