› 2oju

X-ray diffraction
2.4Å resolution

X-ray structure of complex of human cyclophilin J with cyclosporin A

Released:
DOI: 10.2210/pdb2oju/pdb
PDB entry 2oju coloured by chain, front view.
PDB entry 2oju coloured by chain, side view.
PDB entry 2oju coloured by chain, top view.
Source organisms:
Entry authors: Xia Z, Huang L

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163110 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase-like 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 167 amino acids
Theoretical weight: 18.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H2H8 (Residues: 1-161; Coverage: 100%)
Gene name: PPIL3
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
CYCLOSPORIN A Chains: C, D
Molecule details ›
Chains: C, D
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided

Ligands and Environments

No bound ligands
6 modified residues:
Ligand DAL 2 x DAL
Ligand MLE 8 x MLE
Ligand MVA 2 x MVA
Ligand BMT 2 x BMT
Ligand ABA 2 x ABA
Ligand SAR 2 x SAR

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: P3121
Unit cell:
a: 64.387Å b: 64.387Å c: 200.943Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.193 0.237
Expression systems:
  • Escherichia coli
  • Not provided

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