Function and Biology Details
Reaction catalysed:
Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to yield C5a and C5b.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Sushi/SCR/CCP domain
- Serine proteases, trypsin domain
- Peptidase S1A, chymotrypsin family
- von Willebrand factor, type A
- Sushi/SCR/CCP superfamily
- von Willebrand factor A-like domain superfamily
- Serine proteases, trypsin family, serine active site
- Serine proteases, trypsin family, histidine active site
2 more domains
Structure domains:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Complement factor B Bb (preferred)
PDBe Complex ID:
PDB-CPX-133303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Complement factor B
Molecule details ›
Chain: A
Length: 752 amino acids
Theoretical weight: 84.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Structure domains: Thrombin, subunit H
Length: 752 amino acids
Theoretical weight: 84.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P00751 (Residues: 24-764; Coverage: 100%)
Sequence domains:
Structure domains: Thrombin, subunit H
Ligands and Environments
No modified residues
Experiments and Validation Details
wwPDB Validation report is not available for this entry.
X-ray source:
ESRF BEAMLINE ID14-4
Spacegroup:
P3121
Expression system: Homo sapiens
