› 2oks

X-ray diffraction
1.65Å resolution

X-ray Structure of a DNA Repair Substrate Containing an Alkyl Interstrand Crosslink at 1.65 Resolution

Released:
DOI: 10.2210/pdb2oks/pdb
PDB entry 2oks coloured by chain, front view.
PDB entry 2oks coloured by chain, side view.
PDB entry 2oks coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structure of a DNA repair substrate containing an alkyl interstrand cross-link at 1.65 A resolution.
Swenson MC, Paranawithana SR, Miller PS, Kielkopf CL
Biochemistry 46 4545-53 (2007)
PMID: 17375936

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115734 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*CP*AP*AP*(C34)P*GP*TP*TP*GP*G)-3' Chain: A
Molecule details ›
Chain: A
Length: 10 nucleotides
Theoretical weight: 3.06 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
1 modified residue:
Ligand C34 1 x C34

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 31.87Å b: 24.89Å c: 34.35Å
α: 90° β: 114.5° γ: 90°
R-values:
R R work R free
0.182 0.182 0.208
Expression system: Not provided

Quick links

Citations

4 review citations

DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes.
Boer et al. (2009)
3 more

4 mentions without citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
3 more