› 2olx

X-ray diffraction
1.42Å resolution

Structure of NNQQ Peptide from Yeast Prion SUP35

Released:
DOI: 10.2210/pdb2olx/pdb
PDB entry 2olx coloured by chain, front view.
PDB entry 2olx coloured by chain, side view.
PDB entry 2olx coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Atomic structures of amyloid cross-beta spines reveal varied steric zippers.
Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AØ, Riekel C, Eisenberg D
Nature 447 453-7 (2007)
PMID: 17468747

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163113 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NNQQ peptide derived from Yeast Prion Sup35 Chain: A
Molecule details ›
Chain: A
Length: 4 amino acids
Theoretical weight: 502 Da
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P212121
Unit cell:
a: 15.479Å b: 4.915Å c: 30.552Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.183 0.235
Expression system: Not provided

Quick links

Citations

271 review citations

The amyloid state and its association with protein misfolding diseases.
Knowles et al. (2014)
270 more

13 mentions without citation

Structural polymorphism of Alzheimer Abeta and other amyloid fibrils.
Fändrich et al. (2009)
12 more