› 2omm

X-ray diffraction
2Å resolution

GNNQQNY peptide corresponding to residues 7-13 of yeast prion sup35

Released:
DOI: 10.2210/pdb2omm/pdb
PDB entry 2omm coloured by chain, front view.
PDB entry 2omm coloured by chain, side view.
PDB entry 2omm coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
Atomic structures of amyloid cross-beta spines reveal varied steric zippers.
Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AØ, Riekel C, Eisenberg D
Nature 447 453-7 (2007)
PMID: 17468747

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138678 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic peptide chain release factor GTP-binding subunit Chain: A
Molecule details ›
Chain: A
Length: 7 amino acids
Theoretical weight: 837 Da
Source organism: Saccharomyces cerevisiae S288C
Expression system: Not provided
UniProt:
  • Canonical: P05453 (Residues: 7-13; Coverage: 1%)
Gene names: GST1, PNM2, SAL3, SUF12, SUP2, SUP35, YD9395.05, YDR172W

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P212121
Unit cell:
a: 23.324Å b: 4.934Å c: 37.548Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.241 0.252
Expression system: Not provided

Quick links

Citations

269 review citations

The amyloid state and its association with protein misfolding diseases.
Knowles et al. (2014)
268 more

13 mentions without citation

Ubiquitous amyloids.
Pulawski et al. (2012)
12 more