› 2omq

X-ray diffraction
2Å resolution

VEALYL peptide derived from human insulin chain B, residues 12-17

Released:
DOI: 10.2210/pdb2omq/pdb
PDB entry 2omq coloured by chain, front view.
PDB entry 2omq coloured by chain, side view.
PDB entry 2omq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structures of amyloid cross-beta spines reveal varied steric zippers.
Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AØ, Riekel C, Eisenberg D
Nature 447 453-7 (2007)
PMID: 17468747

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134236 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin B chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 6 amino acids
Theoretical weight: 707 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 36-41; Coverage: 7%)
Gene name: INS

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P1
Unit cell:
a: 18.425Å b: 9.613Å c: 21.975Å
α: 90.88° β: 96.12° γ: 100.93°
R-values:
R R work R free
0.205 0.201 0.265
Expression system: Not provided

Quick links

Citations

272 review citations

The amyloid state and its association with protein misfolding diseases.
Knowles et al. (2014)
271 more

15 mentions without citation

Structural complexity of a composite amyloid fibril.
Lewandowski et al. (2011)
14 more