› 2onv

X-ray diffraction
1.61Å resolution

Crystal Structure of the amyloid-fibril forming peptide GGVVIA derived from the Alzheimer's amyloid Abeta (Abeta37-42).

Released:
DOI: 10.2210/pdb2onv/pdb
PDB entry 2onv coloured by chain, front view.
PDB entry 2onv coloured by chain, side view.
PDB entry 2onv coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Atomic structures of amyloid cross-beta spines reveal varied steric zippers.
Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AØ, Riekel C, Eisenberg D
Nature 447 453-7 (2007)
PMID: 17468747

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163117 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
amyloid-fibril forming peptide GGVVIA derived from the Alzheimer's amyloid Abeta Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 515 Da
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P21212
Unit cell:
a: 16.76Å b: 41.134Å c: 4.789Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.228 0.299
Expression system: Not provided

Quick links

Citations

271 review citations

The amyloid state and its association with protein misfolding diseases.
Knowles et al. (2014)
270 more

10 mentions without citation

Amyloid beta: structure, biology and structure-based therapeutic development.
Chen et al. (2017)
9 more