› 2osh

X-ray diffraction
2.2Å resolution

crystal structure of Natratoxin, a snake sPLA2 that blocks A-type K+ channel

Released:
DOI: 10.2210/pdb2osh/pdb
PDB entry 2osh coloured by chain, front view.
PDB entry 2osh coloured by chain, side view.
PDB entry 2osh coloured by chain, top view.
Source organism: Naja atra
Primary publication:
Crystal structure of Natratoxin, a novel snake secreted phospholipaseA2 neurotoxin from Naja atra venom inhibiting A-type K+ currents.
Hu P, Sun L, Zhu ZQ, Hou XW, Wang S, Yu SS, Wang HL, Zhang P, Wang M, Niu LW, Teng MK, Ruan DY
Proteins 72 673-83 (2008)
PMID: 18247353

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107279 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acidic phospholipase A2 natratoxin Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.12 KDa
Source organism: Naja atra
UniProt:
  • Canonical: A4FS04 (Residues: 1-119; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41
Unit cell:
a: 42.078Å b: 42.078Å c: 64.117Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.242

Quick links

Citations

4 citation in other articles

Improved method for the isolation, characterization and examination of neuromuscular and toxic properties of selected polypeptide fractions from the crude venom of the Taiwan cobra Naja naja atra.
Ständker et al. (2012)
3 more

1 mention without citation

A convenient protein library for spectroscopic calibrations.
De Meutter et al. (2020)