› 2ovc

X-ray diffraction
2.07Å resolution

Crystal structure of a coiled-coil tetramerization domain from Kv7.4 channels

Released:
DOI: 10.2210/pdb2ovc/pdb
PDB entry 2ovc coloured by chain, front view.
PDB entry 2ovc coloured by chain, side view.
PDB entry 2ovc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into KCNQ (Kv7) channel assembly and channelopathy.
Howard RJ, Clark KA, Holton JM, Minor DL
Neuron 53 663-75 (2007)
PMID: 17329207

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157527 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily KQT member 4 Chain: A
Molecule details ›
Chain: A
Length: 33 amino acids
Theoretical weight: 3.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56696 (Residues: 610-640; Coverage: 5%)
Gene name: KCNQ4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: I4
Unit cell:
a: 33.185Å b: 33.185Å c: 55.283Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.196 0.224
Expression system: Escherichia coli

Quick links

Citations

31 review citations

The genetic basis of long QT and short QT syndromes: a mutation update.
Hedley et al. (2009)
30 more

4 mentions without citation

The Structure and Topology of α-Helical Coiled Coils.
Lupas et al. (2017)
3 more