› 2ovj

X-ray diffraction
1.49Å resolution

The crystal structure of the human Rac GTPase activating protein 1 (RACGAP1) MgcRacGAP.

Released:
DOI: 10.2210/pdb2ovj/pdb
PDB entry 2ovj coloured by chain, front view.
PDB entry 2ovj coloured by chain, side view.
PDB entry 2ovj coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shrestha L, Papagrigoriou E, Soundararajan M, Elkins J, Johansson C, von Delft F, Pike ACW, Burgess N, Turnbull A, Debreczeni J, Gorrec F, Umeano C, Edwards A, Arrowsmith CH, Weigelt J, Sundstrom M, Doyle DA, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190478 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rac GTPase-activating protein 1 Chain: A
Molecule details ›
Chain: A
Length: 201 amino acids
Theoretical weight: 22.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H0H5 (Residues: 348-546; Coverage: 32%)
Gene names: KIAA1478, MGCRACGAP, RACGAP1
Sequence domains: RhoGAP domain
Structure domains: Rho GTPase activation protein

Ligands and Environments

1 bound ligand:
Ligand 7PE 1 x 7PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 52.913Å b: 53.548Å c: 67.979Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.152 0.176
Expression system: Escherichia coli BL21(DE3)

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