› 2oxj

X-ray diffraction
2Å resolution

Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-p1 with beta-residues at b and f heptad positions.

Released:
DOI: 10.2210/pdb2oxj/pdb
PDB entry 2oxj coloured by chain, front view.
PDB entry 2oxj coloured by chain, side view.
PDB entry 2oxj coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Helix bundle quaternary structure from alpha/beta-peptide foldamers.
Horne WS, Price JL, Keck JL, Gellman SH
J Am Chem Soc 129 4178-80 (2007)
PMID: 17362016

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163134 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
hybrid alpha/beta peptide based on the GCN4-p1 sequence; heptad positions b and f substituted with beta-amino acids Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 34 amino acids
Theoretical weight: 4.16 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
7 modified residues:
Ligand B3K 6 x B3K
Ligand B3D 3 x B3D
Ligand B3E 3 x B3E
Ligand B3S 3 x B3S
Ligand B3Y 3 x B3Y
Ligand B3X 3 x B3X
Ligand B3A 3 x B3A

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P212121
Unit cell:
a: 25.728Å b: 37.641Å c: 92.511Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.219 0.283
Expression system: Not provided

Quick links

Citations

14 review citations

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.
Pelay-Gimeno et al. (2015)
13 more

3 mentions without citation

Foldamers as versatile frameworks for the design and evolution of function.
Goodman et al. (2007)
2 more