› 2oz5

X-ray diffraction
2Å resolution

Crystal structure of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB in complex with the specific inhibitor OMTS

Released:
DOI: 10.2210/pdb2oz5/pdb
PDB entry 2oz5 coloured by chain, front view.
PDB entry 2oz5 coloured by chain, side view.
PDB entry 2oz5 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Structural basis for selective inhibition of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB.
Grundner C, Perrin D, Hooft van Huijsduijnen R, Swinnen D, Gonzalez J, Gee CL, Wells TN, Alber T
Structure 15 499-509 (2007)
PMID: 17437721

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161254 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine specific protein phosphatases domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 296 amino acids
Theoretical weight: 32.37 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P96830 (Residues: 1-276; Coverage: 100%)
Gene name: MT0162
Sequence domains: Tyrosine phosphatase family
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand 7XY 4 x 7XY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 74.396Å b: 72.488Å c: 96.064Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.189 0.249
Expression system: Escherichia coli

Quick links

Citations

12 review citations

New medicines to improve control and contribute to the eradication of malaria.
Wells et al. (2009)
11 more

19 mentions without citation

Copaifera of the Neotropics: A Review of the Phytochemistry and Pharmacology.
da Trindade et al. (2018)
18 more