› 2oz6

X-ray diffraction
2.8Å resolution

Crystal Structure of Virulence Factor Regulator from Pseudomonas aeruginosa in complex with cAMP

Released:
DOI: 10.2210/pdb2oz6/pdb
PDB entry 2oz6 coloured by chain, front view.
PDB entry 2oz6 coloured by chain, side view.
PDB entry 2oz6 coloured by chain, top view.
Source organism: Pseudomonas aeruginosa
Primary publication:
Crystal structure of the Pseudomonas aeruginosa virulence factor regulator.
Cordes TJ, Worzalla GA, Ginster AM, Forest KT
J Bacteriol 193 4069-74 (2011)
PMID: 21665969

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157279 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cAMP-activated global transcriptional regulator Vfr Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 23.54 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli
UniProt:
  • Canonical: P55222 (Residues: 9-214; Coverage: 96%)
Gene names: PA0652, vfr
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CMP 2 x CMP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: I41
Unit cell:
a: 69.95Å b: 69.95Å c: 147.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.251
Expression system: Escherichia coli

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Citations

3 review citations

The Transcriptional Regulators of the CRP Family Regulate Different Essential Bacterial Functions and Can Be Inherited Vertically and Horizontally.
Soberón-Chávez et al. (2017)
2 more

13 mentions without citation

From Deep Mutational Mapping of Allosteric Protein Landscapes to Deep Learning of Allostery and Hidden Allosteric Sites: Zooming in on "Allosteric Intersection" of Biochemical and Big Data Approaches.
Verkhivker et al. (2023)
12 more