› 2p26

X-ray diffraction
1.75Å resolution

Structure of the PHE2 and PHE3 fragments of the integrin beta2 subunit

Released:
DOI: 10.2210/pdb2p26/pdb
PDB entry 2p26 coloured by chain, front view.
PDB entry 2p26 coloured by chain, side view.
PDB entry 2p26 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins.
Shi M, Foo SY, Tan SM, Mitchell EP, Law SK, Lescar J
J Biol Chem 282 30198-206 (2007)
PMID: 17673459

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138492 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin beta-2 Chain: A
Molecule details ›
Chain: A
Length: 280 amino acids
Theoretical weight: 31.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05107 (Residues: 23-535; Coverage: 37%)
Gene names: CD18, ITGB2, MFI7
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 58.489Å b: 30.853Å c: 65.157Å
α: 90° β: 94.29° γ: 90°
R-values:
R R work R free
0.207 0.204 0.253
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Integrin inside-out signaling and the immunological synapse.
Springer et al. (2012)
6 more

6 mentions without citation

Structural biology of complement receptors.
Santos-López et al. (2023)
5 more