› 2p2w

X-ray diffraction
1.9Å resolution

Crystal structure of citrate synthase from Thermotoga maritima MSB8

Released:
DOI: 10.2210/pdb2p2w/pdb
PDB entry 2p2w coloured by chain, front view.
PDB entry 2p2w coloured by chain, side view.
PDB entry 2p2w coloured by chain, top view.
Source organism: Thermotoga maritima
Entry authors: Sugahara M, Kunishima N, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194502 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Citrate synthase Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 42.36 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9WYC6 (Residues: 1-367; Coverage: 100%)
Gene name: TM_0290
Sequence domains: Citrate synthase, C-terminal domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FLC 2 x FLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2221
Unit cell:
a: 87.337Å b: 139.093Å c: 76.749Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.175 0.187
Expression system: Escherichia coli

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