2p3c

X-ray diffraction
2.1Å resolution

Crystal Structure of the subtype F wild type HIV protease complexed with TL-3 inhibitor

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-180223 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase A2 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.74 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6Q004 (Residues: 1-99; Coverage: 100%)
Gene name: pol
Sequence domains: Retroviral aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: LNLS BEAMLINE D03B-MX1, null
Spacegroup: P61
Unit cell:
a: 61.425Å b: 61.425Å c: 80.892Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.194 0.265
Expression system: Escherichia coli BL21(DE3)