› 2p4e

X-ray diffraction
1.98Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-185468 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proprotein convertase subtilisin/kexin type 9 Chains: A, P
Molecule details ›
Chains: A, P
Length: 692 amino acids
Theoretical weight: 74.46 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q8NBP7 (Residues: 1-692; Coverage: 100%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand HG 2 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 62.81Å b: 70.67Å c: 150.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.25
Expression system: Cricetulus griseus

Quick links

Citations

83 review citations

Mechanisms and regulation of cholesterol homeostasis.
Luo et al. (2020)
82 more

20 mentions without citation

The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol.
Poirier et al. (2013)
19 more