› 2p5s

X-ray diffraction
2.15Å resolution

RAB domain of human RASEF in complex with GDP

Released:
DOI: 10.2210/pdb2p5s/pdb
PDB entry 2p5s coloured by chain, front view.
PDB entry 2p5s coloured by chain, side view.
PDB entry 2p5s coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhu H, Wang J, Shen Y, Tempel W, Landry R, Arrowsmith CH, Edwards AM, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184960 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras and EF-hand domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 199 amino acids
Theoretical weight: 22.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IZ41 (Residues: 533-712; Coverage: 24%)
Gene names: RAB45, RASEF
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand GDP 2 x GDP
Ligand UNX 3 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 71.275Å b: 42.524Å c: 75.656Å
α: 90° β: 98.91° γ: 90°
R-values:
R R work R free
0.214 0.211 0.26
Expression system: Escherichia coli

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