› 2pbf

X-ray diffraction
2Å resolution

Crystal structure of a putative protein-L-isoaspartate O-methyltransferase beta-aspartate methyltransferase (PCMT) from Plasmodium falciparum in complex with S-adenosyl-L-homocysteine

Released:
DOI: 10.2210/pdb2pbf/pdb
PDB entry 2pbf coloured by chain, front view.
PDB entry 2pbf coloured by chain, side view.
PDB entry 2pbf coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Entry authors: Wernimont AK, Hassanali A, Lin L, Lew J, Zhao Y, Ravichandran M, Wasney G, Vedadi M, Kozieradzki I, Bochkarev A, Edwards AM, Arrowsmith CH, Weigelt J, Sundstrom M, Hui R, Qiu W, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163157 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-L-isoaspartate O-methyltransferase beta-aspartate methyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 227 amino acids
Theoretical weight: 25.87 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

1 bound ligand:
Ligand SAH 2 x SAH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P32
Unit cell:
a: 75.156Å b: 75.156Å c: 77.389Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.226 0.224 0.268
Expression system: Escherichia coli

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