› 2per

X-ray diffraction
2Å resolution

Crystal Structure of Human Chloride Intracellular Channel protein 2

Released:
DOI: 10.2210/pdb2per/pdb
PDB entry 2per coloured by chain, front view.
PDB entry 2per coloured by chain, side view.
PDB entry 2per coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications.
Mi W, Liang YH, Li L, Su XD
Proteins 71 509-13 (2008)
PMID: 18186468

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127393 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride intracellular channel protein 2 Chain: A
Molecule details ›
Chain: A
Length: 267 amino acids
Theoretical weight: 30.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15247 (Residues: 1-247; Coverage: 100%)
Gene name: CLIC2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MNB 1 x MNB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: P212121
Unit cell:
a: 44.05Å b: 75.927Å c: 80.477Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.216 0.258
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?
Littler et al. (2010)
4 more

4 mentions without citation

A missense mutation in CLIC2 associated with intellectual disability is predicted by in silico modeling to affect protein stability and dynamics.
Witham et al. (2011)
3 more