› 2ph3

X-ray diffraction
1.91Å resolution

Crystal structure of 3-oxoacyl-[acyl carrier protein] reductase TTHA0415 from Thermus thermophilus

Released:
DOI: 10.2210/pdb2ph3/pdb
PDB entry 2ph3 coloured by chain, front view.
PDB entry 2ph3 coloured by chain, side view.
PDB entry 2ph3 coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Entry authors: Swindell II JT, Chen L, Zhu J, Ebihara A, Shinkai A, Kuramitsu S, Yokoyama S, Fu Z-Q, Chrzas J, Rose JP, Wang BC, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178135 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-oxoacyl-[acyl-carrier-protein] reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 245 amino acids
Theoretical weight: 26.24 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5SL78 (Residues: 1-245; Coverage: 100%)
Gene name: TTHA0415
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P62
Unit cell:
a: 76.525Å b: 76.525Å c: 137.562Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.189 0.229
Expression system: Escherichia coli BL21(DE3)

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