› 2ph4

X-ray diffraction
2.05Å resolution

Crystal structure of a novel Arg49 phospholipase A2 homologue from Zhaoermia mangshanensis venom

Released:
DOI: 10.2210/pdb2ph4/pdb
PDB entry 2ph4 coloured by chain, front view.
PDB entry 2ph4 coloured by chain, side view.
PDB entry 2ph4 coloured by chain, top view.
Source organism: Protobothrops mangshanensis
Primary publication:
Crystal structure of a novel myotoxic Arg49 phospholipase A2 homolog (zhaoermiatoxin) from Zhaoermia mangshanensis snake venom: insights into Arg49 coordination and the role of Lys122 in the polarization of the C-terminus.
Murakami MT, Kuch U, Betzel C, Mebs D, Arni RK
Toxicon 51 723-35 (2008)
PMID: 18295812

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-160908 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 homolog zhaoermiatoxin Chains: A, B
Molecule details ›
Chains: A, B
Length: 121 amino acids
Theoretical weight: 14.01 KDa
Source organism: Protobothrops mangshanensis
UniProt:
  • Canonical: P84776 (Residues: 1-121; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

2 bound ligands:
Ligand SO4 5 x SO4
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P64
Unit cell:
a: 72.933Å b: 72.933Å c: 93.938Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.209 0.289

Quick links

Citations

1 review citation

Alpha-type phospholipase A2 inhibitors from snake blood.
Santos-Filho et al. (2017)
9 other articles

1 mention without citation

Effects of Small Molecule Calcium-Activated Chloride Channel Inhibitors on Structure and Function of Accessory Cholera Enterotoxin (Ace) of Vibrio cholerae.
Chatterjee et al. (2015)