Function and Biology Details
Reactions catalysed:
4-amino-2-methyl-5-diphosphomethylpyrimidine + 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate = diphosphate + thiamine phosphate + CO(2)
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphomethyl)pyrimidine
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
homo tetramer (preferred)
Assembly name:
Bifunctional thiamine biosynthesis protein ThiDN (preferred)
PDBe Complex ID:
PDB-CPX-176456 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional thiamine biosynthesis protein ThiDN
Molecule details ›
Chains: A, B, D, E
Length: 192 amino acids
Theoretical weight: 21.86 KDa
Source organism: Methanocaldococcus jannaschii DSM 2661
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Thiamine-phosphate synthase
Structure domains: Class II aldolase/adducin N-terminal domain
Length: 192 amino acids
Theoretical weight: 21.86 KDa
Source organism: Methanocaldococcus jannaschii DSM 2661
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q57688 (Residues: 236-416; Coverage: 43%)
Sequence domains: Thiamine-phosphate synthase
Structure domains: Class II aldolase/adducin N-terminal domain
