› 2pnc

X-ray diffraction
2.4Å resolution

Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine

Released:
DOI: 10.2210/pdb2pnc/pdb
PDB entry 2pnc coloured by chain, front view.
PDB entry 2pnc coloured by chain, side view.
PDB entry 2pnc coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Multiple binding sites for substrates and modulators of semicarbazide-sensitive amine oxidases: kinetic consequences.
Holt A, Smith DJ, Cendron L, Zanotti G, Rigo A, Di Paolo ML
Mol Pharmacol 73 525-38 (2008)
PMID: 17989349

Function and Biology Details

Reaction catalysed: 
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173347 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Primary amine oxidase, liver isozyme Chains: A, B
Molecule details ›
Chains: A, B
Length: 746 amino acids
Theoretical weight: 82.95 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q29437 (Residues: 17-762; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand CU 2 x CU
Ligand CA 4 x CA
Ligand CL 3 x CL
Ligand CLU 2 x CLU
1 modified residue:
Ligand TPQ 2 x TPQ

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM16
Spacegroup: P212121
Unit cell:
a: 78.36Å b: 131.956Å c: 134.159Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.237 0.252

Quick links

Citations

2 review citations

Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO.
Papukashvili et al. (2020)
1 more

2 mentions without citation

Copper active sites in biology.
Solomon et al. (2014)
1 more