› 2pp4

Solution NMR

Solution Structure of ETO-TAFH refined in explicit solvent

Released:
DOI: 10.2210/pdb2pp4/pdb
PDB entry 2pp4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2pp4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2pp4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription.
Wei Y, Liu S, Lausen J, Woodrell C, Cho S, Biris N, Kobayashi N, Wei Y, Yokoyama S, Werner MH
Nat Struct Mol Biol 14 653-61 (2007)
PMID: 17572682

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170346 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein CBFA2T1 Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q06455 (Residues: 119-225; Coverage: 18%)
Gene names: AML1T1, CBFA2T1, CDR, ETO, MTG8, RUNX1T1, ZMYND2
Sequence domains: NHR1 homology to TAF
Structure domains: TAFH/NHR1 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making.
Mangan et al. (2011)
3 more

6 mentions without citation

αα-Hub domains and intrinsically disordered proteins: A decisive combo.
Bugge et al. (2021)
5 more