› 2pql

X-ray diffraction
2.2Å resolution

Crystal Structure of Anopheles gambiae D7R4-tryptamine complex

Released:
DOI: 10.2210/pdb2pql/pdb
PDB entry 2pql coloured by chain, front view.
PDB entry 2pql coloured by chain, side view.
PDB entry 2pql coloured by chain, top view.
Source organism: Anopheles gambiae
Primary publication:
The crystal structure of D7r4, a salivary biogenic amine-binding protein from the malaria mosquito Anopheles gambiae.
Mans BJ, Calvo E, Ribeiro JM, Andersen JF
J Biol Chem 282 36626-33 (2007)
PMID: 17928288

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189636 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Short form salivary protein D7R4 Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 17.1 KDa
Source organism: Anopheles gambiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7PNF2 (Residues: 22-165; Coverage: 100%)
Gene names: AgaP_AGAP008281, D7r4
Sequence domains: PBP/GOBP family
Structure domains: Pheromone/general odorant binding protein domain

Ligands and Environments

1 bound ligand:
Ligand TSS 1 x TSS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P43
Unit cell:
a: 63.101Å b: 63.101Å c: 42.596Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.172 0.248
Expression system: Escherichia coli

Quick links

Citations

6 review citations

An insight into the sialome of blood-feeding Nematocera.
Ribeiro et al. (2010)
5 more

4 mentions without citation

An Overview of D7 Protein Structure and Physiological Roles in Blood-Feeding Nematocera.
Alvarenga et al. (2022)
3 more