› 2pqs

X-ray diffraction
2.4Å resolution

Crystal Structure of the Bovine Lactadherin C2 Domain

Released:
DOI: 10.2210/pdb2pqs/pdb
PDB entry 2pqs coloured by chain, front view.
PDB entry 2pqs coloured by chain, side view.
PDB entry 2pqs coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII.
Lin L, Huai Q, Huang M, Furie B, Furie BC
J Mol Biol 371 717-24 (2007)
PMID: 17583728

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188249 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lactadherin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 159 amino acids
Theoretical weight: 18.1 KDa
Source organism: Bos taurus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q95114 (Residues: 270-427; Coverage: 39%)
Gene name: MFGE8
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P21212
Unit cell:
a: 108.123Å b: 107.788Å c: 82.754Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.235 0.273
Expression system: Komagataella pastoris

Quick links

Citations

10 review citations

The distribution and function of phosphatidylserine in cellular membranes.
Leventis et al. (2010)
9 more

3 mentions without citation

Molecular modeling of retinoschisin with functional analysis of pathogenic mutations from human X-linked retinoschisis.
Sergeev et al. (2010)
2 more