Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126650 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain
Molecule details ›
Chain: A
Length: 44 amino acids
Theoretical weight: 5.11 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
Sequence domains: Thrombin light chain
Structure domains: Thrombin light chain domain
Length: 44 amino acids
Theoretical weight: 5.11 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
- Canonical:
P19221 (Residues: 317-360; Coverage: 7%)
Sequence domains: Thrombin light chain
Structure domains: Thrombin light chain domain
Thrombin heavy chain
Molecule details ›
Chain: B
Length: 258 amino acids
Theoretical weight: 29.95 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 258 amino acids
Theoretical weight: 29.95 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
- Canonical: P19221 (Residues: 361-618; Coverage: 43%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Proteinase-activated receptor 3
Molecule details ›
Chain: C
Length: 13 amino acids
Theoretical weight: 1.57 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
Length: 13 amino acids
Theoretical weight: 1.57 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
- Canonical: O08675 (Residues: 44-56; Coverage: 4%)
