› 2pvy

X-ray diffraction
2.2Å resolution

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.

Released:
DOI: 10.2210/pdb2pvy/pdb
PDB entry 2pvy coloured by chain, front view.
PDB entry 2pvy coloured by chain, side view.
PDB entry 2pvy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Chen H, Ma J, Li W, Eliseenkova AV, Xu C, Neubert TA, Miller WT, Mohammadi M
Mol Cell 27 717-30 (2007)
PMID: 17803937

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149431 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 324 amino acids
Theoretical weight: 37.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21802 (Residues: 458-768; Coverage: 39%)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand ACP 4 x ACP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P1
Unit cell:
a: 70.581Å b: 70.467Å c: 85.69Å
α: 92.19° β: 112.31° γ: 116.19°
R-values:
R R work R free
0.236 0.236 0.276
Expression system: Escherichia coli

Quick links

Citations

44 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
43 more

9 mentions without citation

Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ.
Huang et al. (2016)
8 more