› 2q06

X-ray diffraction
3.3Å resolution

Crystal structure of Influenza A Virus H5N1 Nucleoprotein

Released:
DOI: 10.2210/pdb2q06/pdb
PDB entry 2q06 coloured by chain, front view.
PDB entry 2q06 coloured by chain, side view.
PDB entry 2q06 coloured by chain, top view.
Source organism: Influenza A virus
Primary publication:
Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design.
Ng AK, Zhang H, Tan K, Li Z, Liu JH, Chan PK, Li SM, Chan WY, Au SW, Joachimiak A, Walz T, Wang JH, Shaw PC
FASEB J 22 3638-47 (2008)
PMID: 18614582

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192953 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 504 amino acids
Theoretical weight: 56.84 KDa
Source organism: Influenza A virus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9PX50 (Residues: 1-498; Coverage: 100%)
Gene name: NP
Sequence domains: Influenza virus nucleoprotein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P213
Unit cell:
a: 153.578Å b: 153.578Å c: 153.578Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.202 0.279
Expression system: Escherichia coli

Quick links

Citations

32 review citations

Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis.
Te Velthuis et al. (2016)
31 more

25 mentions without citation

Structures of influenza A proteins and insights into antiviral drug targets.
Das et al. (2010)
24 more