› 2q1h

X-ray diffraction
1.9Å resolution

Ancestral Corticoid Receptor in Complex with Aldosterone

Released:
DOI: 10.2210/pdb2q1h/pdb
PDB entry 2q1h coloured by chain, front view.
PDB entry 2q1h coloured by chain, side view.
PDB entry 2q1h coloured by chain, top view.
Source organism: unidentified
Primary publication:
Crystal structure of an ancient protein: evolution by conformational epistasis.
Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW
Science 317 1544-8 (2007)
PMID: 17702911

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163184 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
AncCR Chain: A
Molecule details ›
Chain: A
Length: 250 amino acids
Theoretical weight: 29.05 KDa
Source organism: unidentified
Expression system: Escherichia coli
Structure domains: Retinoid X Receptor

Ligands and Environments

3 bound ligands:
Ligand NA 2 x NA
Ligand AS4 1 x AS4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P43212
Unit cell:
a: 79.658Å b: 79.658Å c: 113.871Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.222
Expression system: Escherichia coli

Quick links

Citations

52 review citations

Convergence, adaptation, and constraint.
Losos JB. (2011)
51 more

5 mentions without citation

Analyzing protein structure and function using ancestral gene reconstruction.
Harms et al. (2010)
4 more