› 2q1v

X-ray diffraction
1.95Å resolution

Ancestral corticoid receptor in complex with cortisol

Released:
DOI: 10.2210/pdb2q1v/pdb
PDB entry 2q1v coloured by chain, front view.
PDB entry 2q1v coloured by chain, side view.
PDB entry 2q1v coloured by chain, top view.
Source organism: unidentified
Primary publication:
Crystal structure of an ancient protein: evolution by conformational epistasis.
Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW
Science 317 1544-8 (2007)
PMID: 17702911

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163185 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
AncCR Chain: A
Molecule details ›
Chain: A
Length: 250 amino acids
Theoretical weight: 29.05 KDa
Source organism: unidentified
Expression system: Escherichia coli
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand PDN 1 x PDN
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 79.873Å b: 79.873Å c: 114.588Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.233
Expression system: Escherichia coli

Quick links

Citations

54 review citations

Convergence, adaptation, and constraint.
Losos JB. (2011)
53 more

5 mentions without citation

Crystal structure of an ancient protein: evolution by conformational epistasis.
Ortlund et al. (2007)
4 more