› 2q2j

X-ray diffraction
1.65Å resolution

Crystal structure of PrTX-I, a PLA2 homolog from Bothrops pirajai

Released:
DOI: 10.2210/pdb2q2j/pdb
PDB entry 2q2j coloured by chain, front view.
PDB entry 2q2j coloured by chain, side view.
PDB entry 2q2j coloured by chain, top view.
Source organism: Bothrops pirajai
Primary publication:
Comparative structural studies on Lys49-phospholipases A(2) from Bothrops genus reveal their myotoxic site.
dos Santos JI, Soares AM, Fontes MR
J Struct Biol 167 106-16 (2009)
PMID: 19401234

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160620 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 homolog piratoxin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 121 amino acids
Theoretical weight: 13.77 KDa
Source organism: Bothrops pirajai
UniProt:
  • Canonical: P82287 (Residues: 1-121; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand TRS 2 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P3121
Unit cell:
a: 55.883Å b: 55.883Å c: 127.913Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.214 0.258

Quick links

Citations

3 review citations

Snake venom Lys49 myotoxins: From phospholipases A(2) to non-enzymatic membrane disruptors.
Lomonte et al. (2012)
2 more

5 mentions without citation

Structural and functional studies of a bothropic myotoxin complexed to rosmarinic acid: new insights into Lys49-PLA₂ inhibition.
Dos Santos et al. (2011)
4 more