› 2q4v

X-ray diffraction
1.84Å resolution

Ensemble refinement of the protein crystal structure of thialysine n-acetyltransferase (SSAT2) from Homo sapiens

Released:
DOI: 10.2210/pdb2q4v/pdb
PDB entry 2q4v coloured by chain, ensemble of 8 models, front view.
PDB entry 2q4v coloured by chain, ensemble of 8 models, side view.
PDB entry 2q4v coloured by chain, ensemble of 8 models, top view.
Source organism: Homo sapiens
Primary publication:
Ensemble refinement of protein crystal structures: validation and application.
Levin EJ, Kondrashov DA, Wesenberg GE, Phillips GN
Structure 15 1040-52 (2007)
PMID: 17850744

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188483 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thialysine N-epsilon-acetyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 170 amino acids
Theoretical weight: 19.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96F10 (Residues: 2-170; Coverage: 99%)
Gene names: SAT2, SSAT2
Sequence domains: Acetyltransferase (GNAT) family
Structure domains: Aminopeptidase

Ligands and Environments


Cofactor: Ligand ACO 1 x ACO
No bound ligands
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 54.583Å b: 83.621Å c: 87.548Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.183 0.234
Expression system: Escherichia coli

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Citations

19 review citations

Enzymes in jasmonate biosynthesis - structure, function, regulation.
Schaller et al. (2009)
18 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)