› 2q81

X-ray diffraction
2.1Å resolution

Crystal Structure of the Miz-1 BTB/POZ domain

Released:
DOI: 10.2210/pdb2q81/pdb
PDB entry 2q81 coloured by chain, front view.
PDB entry 2q81 coloured by chain, side view.
PDB entry 2q81 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain.
Stead MA, Trinh CH, Garnett JA, Carr SB, Baron AJ, Edwards TA, Wright SC
J Mol Biol 373 820-6 (2007)
PMID: 17880999

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer (preferred)
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-171533 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger and BTB domain-containing protein 17 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 119 amino acids
Theoretical weight: 13.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13105 (Residues: 2-115; Coverage: 14%)
Gene names: MIZ1, ZBTB17, ZNF151, ZNF60
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

1 bound ligand:
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: C2221
Unit cell:
a: 65.535Å b: 128.522Å c: 116.038Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.181 0.229
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The role of MIZ-1 in MYC-dependent tumorigenesis.
Wiese et al. (2013)
1 more

5 mentions without citation

Structure of the human Nac1 POZ domain.
Stead et al. (2009)
4 more