› 2q91

X-ray diffraction
1.63Å resolution

Structure of the Ca2+-Bound Activated Form of the S100A4 Metastasis Factor

Released:
DOI: 10.2210/pdb2q91/pdb
PDB entry 2q91 coloured by chain, front view.
PDB entry 2q91 coloured by chain, side view.
PDB entry 2q91 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA.
Malashkevich VN, Varney KM, Garrett SC, Wilder PT, Knight D, Charpentier TH, Ramagopal UA, Almo SC, Weber DJ, Bresnick AR
Biochemistry 47 5111-26 (2008)
PMID: 18410126

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150750 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 101 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26447 (Residues: 1-101; Coverage: 100%)
Gene names: CAPL, MTS1, S100A4
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P3221
Unit cell:
a: 52.424Å b: 52.424Å c: 140.419Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.185 0.217
Expression system: Escherichia coli

Quick links

Citations

14 review citations

S100A4 and metastasis: a small actor playing many roles.
Boye et al. (2010)
13 more

14 mentions without citation

S100 proteins as therapeutic targets.
Bresnick AR. (2018)
13 more