› 2qae

X-ray diffraction
1.9Å resolution

Crystal Structure Analysis of Trypanosoma cruzi Lipoamide dehydrogenase

Released:
DOI: 10.2210/pdb2qae/pdb
PDB entry 2qae coloured by chain, front view.
PDB entry 2qae coloured by chain, side view.
PDB entry 2qae coloured by chain, top view.
Source organism: Trypanosoma cruzi
Entry authors: Werner C, Krauth-Siegel RL, Stubbs MT, Klebe G

Function and Biology Details

Reaction catalysed: 
Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161037 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydrolipoyl dehydrogenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 468 amino acids
Theoretical weight: 49.46 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli
UniProt:
  • Canonical: P90597 (Residues: 10-477; Coverage: 98%)
Gene name: LPD
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 60.7Å b: 104.9Å c: 147.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 0.217
Expression system: Escherichia coli

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