› 2qff

X-ray diffraction
1.8Å resolution

Crystal structure of Staphylococcal Complement Inhibitor

Released:
DOI: 10.2210/pdb2qff/pdb
PDB entry 2qff coloured by chain, front view.
PDB entry 2qff coloured by chain, side view.
PDB entry 2qff coloured by chain, top view.
Source organism: Staphylococcus aureus subsp. aureus MRSA252
Primary publication:
Staphylococcal complement inhibitor: structure and active sites.
Rooijakkers SH, Milder FJ, Bardoel BW, Ruyken M, van Strijp JA, Gros P
J. Immunol. 179 2989-98 (2007)
PMID: 17709514

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179661 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Staphylococcal complement inhibitor Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 9.53 KDa
Source organism: Staphylococcus aureus subsp. aureus MRSA252
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6GFB4 (Residues: 32-113; Coverage: 97%)
Gene names: SAR2035, scn
Sequence domains: Staphylococcal complement inhibitor SCIN
Structure domains: Substrate Binding Domain Of Dnak; Chain:A; Domain 2

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 23.017Å b: 42.775Å c: 63.91Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.201 0.226
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Molecular mechanisms of complement evasion: learning from staphylococci and meningococci.
Serruto et al. (2010)
8 more

6 mentions without citation

Complement evasion by human pathogens.
Lambris et al. (2008)
5 more