› 2qfz

X-ray diffraction
2.1Å resolution

Crystal structure of human TBC1 domain family member 22A

Released:
DOI: 10.2210/pdb2qfz/pdb
PDB entry 2qfz coloured by chain, front view.
PDB entry 2qfz coloured by chain, side view.
PDB entry 2qfz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tong Y, Tempel W, Dimov S, Dong A, Landry R, Arrowsmith CH, Edwards AM, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186711 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TBC1 domain family member 22A Chains: A, B
Molecule details ›
Chains: A, B
Length: 345 amino acids
Theoretical weight: 41.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WUA7 (Residues: 191-517; Coverage: 63%)
Gene names: C22orf4, TBC1D22A
Sequence domains: Rab-GTPase-TBC domain
Structure domains: Ypt/Rab-GAP domain of gyp1p, domain 3

Ligands and Environments

1 bound ligand:
Ligand UNX 12 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12B
Spacegroup: P21
Unit cell:
a: 42.911Å b: 121.515Å c: 66.278Å
α: 90° β: 93.64° γ: 90°
R-values:
R R work R free
0.205 0.202 0.257
Expression system: Escherichia coli

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