› 2qhd

X-ray diffraction
1.95Å resolution

Crystal structure of ecarpholin S (ser49-PLA2) complexed with fatty acid

Released:
DOI: 10.2210/pdb2qhd/pdb
PDB entry 2qhd coloured by chain, front view.
PDB entry 2qhd coloured by chain, side view.
PDB entry 2qhd coloured by chain, top view.
Source organism: Echis carinatus
Primary publication:
Structural characterization of myotoxic ecarpholin S from Echis carinatus venom.
Zhou X, Tan TC, Valiyaveettil S, Go ML, Kini RM, Velazquez-Campoy A, Sivaraman J
Biophys J 95 3366-80 (2008)
PMID: 18586854

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155790 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 homolog ecarpholin S Chains: A, B
Molecule details ›
Chains: A, B
Length: 122 amino acids
Theoretical weight: 13.84 KDa
Source organism: Echis carinatus
UniProt:
  • Canonical: P48650 (Residues: 1-122; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:
Ligand DAO 2 x DAO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P3121
Unit cell:
a: 62.096Å b: 62.096Å c: 124.252Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.228 0.268

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Citations

5 review citations

100 Years of Suramin.
Wiedemar et al. (2020)
4 more

3 mentions without citation

Structural characterization of myotoxic ecarpholin S from Echis carinatus venom.
Zhou et al. (2008)
2 more