2qkh

X-ray diffraction
1.9Å resolution

Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-140731 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Gastric inhibitory polypeptide Chain: B
Molecule details ›
Chain: B
Length: 42 amino acids
Theoretical weight: 4.99 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09681 (Residues: 52-93; Coverage: 32%)
Gene name: GIP
Sequence domains: Peptide hormone
Gastric inhibitory polypeptide receptor Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P48546 (Residues: 24-138; Coverage: 26%)
Gene name: GIPR
Sequence domains: Hormone receptor domain
Structure domains: GPCR, family 2, extracellular hormone receptor domain

Ligands and Environments

Carbohydrate polymer : NEW Components: ZB1, GLC, ZB2, ZB3, ZB0
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: R32
Unit cell:
a: 84.007Å b: 84.007Å c: 180.947Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.166 0.183
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)