› 2qks

X-ray diffraction
2.2Å resolution

Crystal structure of a Kir3.1-prokaryotic Kir channel chimera

Released:
DOI: 10.2210/pdb2qks/pdb
PDB entry 2qks coloured by chain, front view.
PDB entry 2qks coloured by chain, side view.
PDB entry 2qks coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of a Kir3.1-prokaryotic Kir channel chimera.
Nishida M, Cadene M, Chait BT, MacKinnon R
EMBO J 26 4005-15 (2007)
PMID: 17703190

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159062 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
G protein-activated inward rectifier potassium channel 1; Inward rectifier potassium channel Chains: A, B
Molecule details ›
Chains: A, B
Length: 321 amino acids
Theoretical weight: 36.18 KDa
Source organisms: Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P63250 (Residues: 41-87, 179-371; Coverage: 47%)
  • Canonical: Q146M9 (Residues: 63-142; Coverage: 25%)
Gene names: Bxe_A4289, Girk1, Kcnj3
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand BNG 1 x BNG
Ligand K 12 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P4
Unit cell:
a: 98.416Å b: 98.416Å c: 92.624Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.231 0.256
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

39 review citations

Inwardly rectifying potassium channels: their structure, function, and physiological roles.
Hibino et al. (2010)
38 more

37 mentions without citation

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.
Lüscher et al. (2010)
36 more