› 2qog

X-ray diffraction
2.28Å resolution

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150146 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phospholipase A2 crotoxin basic chain CBa2 Chains: A, D
Molecule details ›
Chains: A, D
Length: 122 amino acids
Theoretical weight: 14.28 KDa
Source organism: Crotalus durissus terrificus
UniProt:
  • Canonical: P24027 (Residues: 17-138; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain
Phospholipase A2 crotoxin basic subunit CBc Chains: B, C
Molecule details ›
Chains: B, C
Length: 122 amino acids
Theoretical weight: 14.22 KDa
Source organism: Crotalus durissus terrificus
UniProt:
  • Canonical: P62022 (Residues: 17-138; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P212121
Unit cell:
a: 72.895Å b: 81.159Å c: 100.039Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.228 0.26

Quick links

Citations

5 review citations

Protein complexes in snake venom.
Doley et al. (2009)
4 more

15 mentions without citation

Phospholipase A2 isolated from the venom of Crotalus durissus terrificus inactivates dengue virus and other enveloped viruses by disrupting the viral envelope.
Muller et al. (2014)
14 more