› 2qro

X-ray diffraction
3.45Å resolution

Human Deoxycytidine kinase dAMP, UDP, Mg ion product complex

Released:
DOI: 10.2210/pdb2qro/pdb
Model geometry
Fit model/data
PDB entry 2qro coloured by chain, front view.
PDB entry 2qro coloured by chain, side view.
PDB entry 2qro coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human deoxycytidine kinase product complexes.
Soriano EV, Clark VC, Ealick SE
Acta Crystallogr D Biol Crystallogr 63 1201-7 (2007)
PMID: 18084067

Function and Biology Details

Reactions catalysed: 
ATP + deoxyguanosine = ADP + dGMP
NTP + deoxycytidine = NDP + dCMP
ATP + deoxyadenosine = ADP + dAMP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151058 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxycytidine kinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 280 amino acids
Theoretical weight: 32.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27707 (Residues: 1-260; Coverage: 100%)
Gene name: DCK
Sequence domains: Deoxynucleoside kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:
Ligand MG 4 x MG
Ligand UDP 4 x UDP
Ligand D5M 4 x D5M
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P43212
Unit cell:
a: 93.688Å b: 93.688Å c: 332.408Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.257
Expression system: Escherichia coli

Quick links