› 2qs2

X-ray diffraction
1.8Å resolution

Crystal structure of the GluR5 ligand binding core dimer in complex with UBP318 at 1.80 Angstroms resolution

Released:
DOI: 10.2210/pdb2qs2/pdb
PDB entry 2qs2 coloured by chain, front view.
PDB entry 2qs2 coloured by chain, side view.
PDB entry 2qs2 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists.
Alushin GM, Jane D, Mayer ML
Neuropharmacology 60 126-34 (2011)
PMID: 20558186

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149794 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.21 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P22756 (Residues: 446-559, 682-821; Coverage: 28%)
Gene names: Glur5, Grik1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand CL 2 x CL
Ligand 1PE 2 x 1PE
Ligand UBF 2 x UBF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2221
Unit cell:
a: 98.124Å b: 98.176Å c: 128.594Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.219
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
4 more

4 mentions without citation

Ligand pose and orientational sampling in molecular docking.
Coleman et al. (2013)
3 more