› 2qs4

X-ray diffraction
1.58Å resolution

Crystal structure of the GluR5 ligand binding core dimer in complex with LY466195 at 1.58 Angstroms resolution

Released:
DOI: 10.2210/pdb2qs4/pdb
PDB entry 2qs4 coloured by chain, front view.
PDB entry 2qs4 coloured by chain, side view.
PDB entry 2qs4 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists.
Alushin GM, Jane D, Mayer ML
Neuropharmacology 60 126-34 (2011)
PMID: 20558186

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149794 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 258 amino acids
Theoretical weight: 29.21 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P22756 (Residues: 446-559, 682-821; Coverage: 28%)
Gene names: Glur5, Grik1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand NH4 2 x NH4
Ligand LY5 4 x LY5
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: R3
Unit cell:
a: 89.241Å b: 89.241Å c: 330.365Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.16 0.158 0.199
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
4 more

6 mentions without citation

Structural protein-ligand interaction fingerprints (SPLIF) for structure-based virtual screening: method and benchmark study.
Da et al. (2014)
5 more