› 2qs9

X-ray diffraction
1.72Å resolution

Crystal structure of the human retinoblastoma-binding protein 9 (RBBP-9). NESG target HR2978

Released:
DOI: 10.2210/pdb2qs9/pdb
PDB entry 2qs9 coloured by chain, front view.
PDB entry 2qs9 coloured by chain, side view.
PDB entry 2qs9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human retinoblastoma binding protein 9.
Vorobiev SM, Su M, Seetharaman J, Huang YJ, Chen CX, Maglaqui M, Janjua H, Proudfoot M, Yakunin A, Xiao R, Acton TB, Montelione GT, Tong L
Proteins 74 526-9 (2009)
PMID: 19004028

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131152 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine hydrolase RBBP9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 194 amino acids
Theoretical weight: 22.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75884 (Residues: 1-186; Coverage: 100%)
Gene names: BOG, RBBP10, RBBP9
Sequence domains: Serine hydrolase
Structure domains: alpha/beta hydrolase

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 37.081Å b: 130.34Å c: 39.047Å
α: 90° β: 115.87° γ: 90°
R-values:
R R work R free
0.183 0.183 0.203
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The metabolic serine hydrolases and their functions in mammalian physiology and disease.
Long et al. (2011)
1 more

3 mentions without citation

Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers.
Vorobiev et al. (2012)
2 more